Nicotine from edible Solanaceae and risk of Parkinson disease.

New research reveals that Solanaceae — a flowering plant family with some species producing foods that are edible sources of nicotine — may provide a protective effect against Parkinson’s disease. The study appearing today inAnnals of Neurology, a journal of the American Neurological Association and Child Neurology Society, suggests that eating foods that contain even a small amount of nicotine, such as peppers and tomatoes, may reduce risk of developing Parkinson’s.

Nicotine from edible Solanaceae and risk of Parkinson disease.
Nielsen SS, Franklin GM, Longstreth WT, Swanson PD, Checkoway H.
Abstract
OBJECTIVE:
To test whether risk of Parkinson disease (PD) is associated with consumption of nicotine-containing edibles from the same botanical family as tobacco, Solanaceae, including peppers, tomatoes, and potatoes.
METHODS:
In a population-based study with 490 newly diagnosed idiopathic PD cases diagnosed during 1992-2008 at the University of Washington Neurology Clinic or Group Health Cooperative in western Washington State and 644 unrelated, neurologically normal controls, we examined whether PD was associated with self-reported typical frequency of consumption of peppers, tomatoes, tomato juice, and potatoes during adulthood, while adjusting for consumption of other vegetables, age, sex, race/ethnicity, tobacco use, and caffeine.
RESULTS:
PD was inversely associated with consumption of all edible Solanaceae combined (relative risk [RR] = 0.81, 95% confidence interval [CI] = 0.65-1.01 per time per day), but not consumption of all other vegetables combined (RR = 1.00, 95% CI = 0.92-1.10). The trend strengthened when we weighted edible Solanaceae by nicotine concentration (ptrend  = 0.004). An inverse association was also evident for peppers specifically (ptrend  = 0.005). The potentially protective effect of edible Solanaceae largely occurred in men and women who had never used tobacco or who had smoked cigarettes.

INTERPRETATION:
Dietary nicotine or other constituents of tobacco and peppers may reduce PD risk. However, confirmation and extension of these findings are needed to strengthen causal inferences that could suggest possible dietary or pharmaceutical interventions for PD prevention. Ann Neurol 2013.

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Magnetic fields in the treatment of Parkinson’s disease.

Magnetic fields in the treatment of Parkinson’s disease.

Sandyk R, Anninos PA, Tsagas N, Derpapas K.

Source

Democrition University of Thrace, Department of Medical Physics and Polytechnic School, Alexandroupolis and Xanthi, Greece.

Abstract

Levodopa-induced dyskinesias are a common complication of chronic dopaminergic therapy in patients with Parkinson’s disease (PD). The overall prevalence of levodopa-induced dyskinesias ranges from 40%-90% and is related to the underlying disease process, pharmacologic factors, and to the duration of high dose levodopa therapy. The mechanisms underlying the emergence of levodopa-induced dyskinesias are unknown, although most investigators favor the theory that striatal dopamine receptor supersensitivity is directly responsible for the development of these abnormal movements. In laboratory animals, the pineal hormone melatonin has been shown to regulate striatal dopaminergic activity and block levodopa-induced dyskinesias (Cotzias et al., 1971). Since the pineal gland is known to be a magnetosensitive organ and as application of external magnetic fields has been shown to alter melatonin secretion, we studied the effects of application of external artificial weak magnetic fields in a Parkinsonian patient with severe levodopa-induced dyskinesias (“on-off”). Application of weak magnetic fields with a frequency of 2 Hz and intensity of 7.5 picotesla (pT) for a 6 minute period resulted in a rapid and dramatic attenuation of Parkinsonian disability and an almost complete resolution of the dyskinesias. This effect persisted for about 72 hours after which the patient regressed to his pretreatment state. To ascertain if the responses elicited in the laboratory were reproducible, the patient was instructed to apply magnetic fields of the same characteristics daily at home. These subsequent treatments paralleled the initial response with a sustained improvement being maintained during an observation period lasting at least one month. This case demonstrates the efficacy of weak magnetic fields in the treatment of Parkinsonism and motor complications of chronic levodopa therapy.

Call or e-mail if you are interested in trying PEMF for Parkinsons Disease.

 

Chiropractic for Parkinson’s? Be Cautious By Dean P. Sutherland, M.D. Ph.D.

Below see a article from Dean P. Sutherland, M.D. Ph.D. You can then read my response to his article. It’s sad to see the medical community discount things they aren’t familiar with or understand.

Many patients are interested alternative therapy for medical diseases, with at least 80% of adults taking some form of vitamins, herbal preparations, acupuncture, biofeedback, Tai Chi, Yoga, etc. With regard to PD, data from small studies show that PD patients have improvement in sense of well-being and stiffness with both Tai Chi and Yoga, but no changes in motor performance. Data regarding chiropractic treatment for PD has not been available or reliable.
My approach to PD has always been “as long as it will not hurt you, it’s probably okay, as long as you don’t use it as your sole method of treatment.” By “hurt you” I mean physical damage or injury, worsening of PD, significant pain, or mental/psychological damage. I would include giving false hope or making unfounded claims as being harmful to patients, emotionally, financially, and often physically.
There are clearly some well-educated, conservative chiropracters who offer treatments locally for a variety of well-established conditions. As long as PD patients are aware that there is no good scientific evidence either way regarding effectiveness for PD and they look carefully at what is being offered or claimed by the chiropracter, then they may choose to try it.
Of particular concern, however, is when fantastical, non-scientific claims are being made. These can be found locally as well as nationally. I would caution patients to avoid some treatments in particular, especially those that are invasive. “Functional Cranial Release,” for instance, is a non-scientific and somewhat risky procedure that is being touted as a treatment for just about everything, including PD. It involves a balloon being inserted into the nasal passages, then expanded, then contracted and removed, with claims that it is restoring or correcting cranial abnormalities. It is further claimed that this procedure treats Alzheimer’s, headaches, migraines, ringing in the ears, fibromyalgia, and the list goes on and on. The purported mechanism of patient improvement is by “improving blood flow and oxygenation” to the brain and “releasing nerves.” Patients are reportedly dramatically improved and, sometimes, told they can stop taking their medications. Nasal damage has been clearly documented in some patients who underwent this procedure.
This meets the classic criteria for a scam: unproven claims, lack of scientific evidence, miraculous reversal of degenerative processes, panacea (good for anything), aggressive marketing with glowing testimonials, lack of anatomical/physiological basis in reality. See http://www.quackwatch.com/
To summarize, patients should not avoid chiropracters as a group, but, just as in any profession, there are a few practitioners and treatments who should be avoided at all cost.

DR John Lieurance says:Your comment is awaiting moderation.

January 16, 2013 at 9:53 pm

I’m flattered that you have mentioned my work in your blog. The endo-nasal work is a very small part of our treatment with PD. Although compared to many of the other modalities I use it can have some profound effects on brain function and creating positive plastic changes centrally in the brain as well as helping many patients absorb NO2 through he sinus’ and improve nasal breathing in mouth breathers. It is by no means a panacea and is not presented such at my office as you state in your blog. Much of the work I do with PD and TBI uses basic neurology applications based on principles of the individual metabolic capacity and the specific presynaptic pools I am looking to fire. I would hate for you to mis lead your readers as to what I am doing for PD. I would be interested in lunch anytime to discuss how we can work together in our community to serve the PD patients. Also the endo-nasal is extremely safe. Certainly not a risk for any patient to have this treatment based on almost 20 years of performing thousands of treatment.

 

Sincerely

Dr. John Lieurance

New Research shows Pesticide / Pakinsons connection! Learn how you an protect yourself with Glutathione.

Chronic systemic pesticide exposure reproduces features of Parkinson’s disease.

Ranjita Betarbet1, 2, Todd B. Sherer1, 2, Gillian MacKenzie1, Monica Garcia-Osuna1, Alexander V. Panov1 & J. Timothy Greenamyre1

1  Department of Neurology, Emory University, 1639 Pierce Drive, WMB 6000, Atlanta, Georgia 30322, USA

The cause of Parkinson’s disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic defect in mitochondrial complex I. We report that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and alpha-synuclein. These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD.

Comment:

How can you protect yourself? Glutathione acts like fly paper and wraps around then carries the toxins such as heavy metals and pesticides out of the body. Reseaech has proven that PArkinson’s in due to oxidative stress in the S. Nigra in the brain and low Glutathione levels contribute to the damage. Protecting your brain by supplementing with Glutathione is a smart choice. Remember you cann’t take Glutathione orally so suppositories and nebulization are a great option.

Oxidative stress as a cause of nigral cell death in Parkinson’s disease and incidental lewy body disease

The Lewy Bodies they describe below are due to oxidative stress. This can be improved. Generally due to low Glutathione levels there is damage that occurs in the SN. Glutathione is the bodies main anti-oxidant. See GlutaGenic.com for more on this and consider signing up for the free 7 secrets to raising glutathione.

 

Abstract

We examine the evidence for free radical involvement and oxidative stress in the pathological process underlying Parkinson’s disease, from postmortem brain tissue. The concept of free radical involvement is supported by enhanced basal lipid peroxidation in substantia nigra in patients with Parkinson’s disease, demonstrated by increased levels of malondialdehyde and lipid hydroperoxides. The activity of many of the protective mechanisms against oxidative stress does not seem to be significantly altered in the nigra in Parkinson’s disease. Thus, activities of catalase and glutathione peroxidase are more or less unchanged, as are concentrations of vitamin C and vitamin E. The activity of mitochondrial superoxide dismutase and the levels of the antioxidant ion zinc are, however, increased, which may reflect oxidative stress in substantia nigra. Levels of reduced glutathione are decreased in nigra in Parkinson’s disease; this decrease does not occur in other brain areas or in other neurodegenerative illnesses affecting this brain region (i.e., multiple system atrophy, progressive supranuclear palsy). Altered glutathione metabolism may prevent inactivation of hydrogen peroxide and enhance formation of toxic hydroxyl radicals. In brain material from patients with incidental Lewy body disease (presymptomatic Parkinson’s disease), there is no evidence for alterations in iron metabolism and no significant change in mitochondrial complex I function. The levels of reduced glutathione in substantia nigra, however, are reduced to the same extent as in advanced Parkinson’s disease. These data suggest that changes in glutathione function are an early component of the pathological process of Parkinson’s disease. The data presented suggest (1) there is oxidative stress in the substantia nigra at the time of death in advanced Parkinson’s disease that manifests in terms of increased lipid peroxidation, superoxide dismutase activity, and zinc levels; (2) there is a major impairment of the glutathione pathway in Parkinson’s disease; and (3) alterations in reduced glutathione levels may occur very early in the illness.

AGEING AND PARKINSON’S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

The following article is a bit technical. The Lewy Bodies they describe below are due to oxidative stress. This can be improved as the main culprits is poor circulation which is improved with better cranial function. SeeFunctionalCranialRelease.com for more on this. The other issue is generally due to Glutathione levels. Glutathione is the bodies main anti-oxidant. SeeGlutaGenic.com for more on this and consider signing up for the free 7 secrets to raising glutathione.

The micro-architecture of the substantia nigra was studied in control cases of varying age and patients with parkinsonism. A single 7μ section stained with haematoxylin and eosin was examined at a specific level within the caudal nigra using strict criteria. The pars compacta was divided into a ventral and a dorsaltier, and each tier was further subdivided into 3 regions. In 36 control cases there was a linear fallout of pigmented neurons with advancing age in the pars compacta of the caudal substantia nigra at a rate of 4.7% per decade. Regionally, the lateral ventral tier was relatively spared (2.1% loss per decade) compared with the medial ventral tier (5.4%) and the dorsal tier (6.9%). In 20 Parkinson’s disease (PD) cases of varying disease duration there was an exponential loss of pigmented neurons with a 45% loss in the first decade. Regionally, the pattern was opposite to ageing. Loss was greatest in the lateral ventral tier (average loss 91%) followed by the medial ventral tier (71%) and the dorsal tier (56%). The presymptomatic phase of PD from the onset of neuronal loss was estimated to be about 5 yrs. This phase is represented by incidental Lewy body cases: individuals who die without clinical signs of PD or dementia, but who are found to have Lewy bodies at post-mortem. In 7 cases cell loss was confined to the lateral ventral tier (average loss 52%) congruent with the lateral ventral selectivity of symptomatic PD. It was calculated that at the onset of symptoms there was a 68% cell loss in the lateral ventral tier and a 48% loss in the caudal nigra as a whole. The regional selectivity of PD is relatively specific. In 15 cases of striatonigral degeneration the distribution of cell loss was similar, but the loss in the dorsal tier was greater than PD by 21%. In 14 cases of Steele-Richardson- Olszewski syndrome (SRO) there was no predilection for the lateral ventral tier, but a tendency to involve the medial nigra and spare the lateral. These findings suggest that agerelated of pigmented nigral cells is not an important factor in the pathogenesis of PD.

 

Parkinson’s Treatment Tips: What’s Keeping Stem Cells from Being a Major Parkinson’s Breakthrough.

Parkinson’s Treatment Tips: What’s Keeping Stem Cells from Being a Major Parkinson’s Breakthrough

Posted on October 27, 2011 by Michael Okun
Below is an article that was put out with either limited understanding of stem cells and there current application. Before you read the article please understand that adult stem cell lines have been researched in over 80,000 publications with absolutely no negative effects reported. Adult stem cell lines are autologous meaning they come from the same patient. Autologous adult stem cells will be attracted to inflammation or area’s where there is damage. This is where the article falls short with their understanding. I agree that there are often many area’s of the brain that are in need of repair with Parkinsons and when stem cells are introduced globally into the central nervous system systematically over time there can be a repopulation of these pools of neurons in various area’s of the brain. Stem cells always need to be introduces with the appropriate growth factors to both activate and assist in the differentiation into neurons. This is what is accomplished with the combination of blood derived growth factors, photo activation and even ozone activation.
Below is from AdiStem. They are describing the activation of stem cells using blood derived growth factors and photo activation.
Activated Stem CellsFigure 1.1. Activated Stem Cells
When stem cells were injected via IV drip without activation using AdiStem technology, the unactivated stem cells did not go to the site of the injury. (See Figure 1.2.)

Unactivated Stem CellsFigure 1.2. Unactivated Stem Cells
This is combination with the use of functional neurology where specific area’s of the brain are activated using targeted therapeutic treatment modalities. Example would be to appropriately drive the dopaminergic system of the brain while the individual is in the active phase of stem cell introduction.
Ok here is the article.

What are the problems/challenges of stem cells for Parkinson’s disease that are keeping it from becoming a major treatment?

There are significant problems with stem cells as a potential savior therapy for Parkinson’s disease.  First, when you take a cell and make it divide you must be able to turn it on and off.  If you cannot control growth of the cells, then they have the potential to form cancers.  This limitation of stem cell therapy is an area that has drawn increasing attention from researchers and funding organizations, and pairing stem cell therapy with gene therapy for example may help to alleviate this issue.  The other major issue with stem cell therapy is that it fails to address the complexity of Parkinson’s disease.  Parkinson’s disease was long thought to be a simple loss of dopaminergic cells in an area of the midbrain called the substantia nigra.  We are now aware that there is a much greater level of complexity to this disease and that multiple motor and non-motor circuits and regions (Alexander, DeLong et al. 1986; Alexander, Crutcher et al. 1990) throughout the brain area affected.  Additionally, Parkinson’s disease may actually be multiple diseases with similar manifestations.  This issue of multiple regions as well as the issue of addressing multiple motor and non-motor symptoms may prove limiting for stem cells or for any transplantation strategy.  An important area of research therefore, will need to be investigation into “how to encourage stem cells” to repopulate and repair multiple brain circuits in many brain regions (Arias-Carrion, Freundlieb et al. 2007; Steindler 2007; Trzaska and Rameshwar 2007; Wang, Chen et al. 2007; Deuschl 2008; Svendsen 2008; Wijeyekoon and Barker 2008; Xi and Zhang 2008).

University of Florida Parkinson’s Treatment Tips blog written by Michael S. Okun, M.D., You can also read Dr. Okun’s book Ask the Doctor about Parkinson’s Disease (Demos Publishing).

Voice Recognition Software Can Diagnose Parkinson’s!

Voice Recognition Software Can Diagnose Parkinson’s

“Siri, do I have Parkinson’s?” That might sound flippant, but actually new research shows that it’s possible to detect Parkinson’s symptoms simply by using algorithms to detect changes in voice recordings. {Siri is the iphone voice recognition app.}

Parkinson’s, a degenerative disorder of the central nervous system, is usually diagnosed through analysis of symptoms along with expensive medical imaging to rule out other conditions—though there is currently no concrete method for detecting it.

Max Little, from the University of Oxford, has different ideas. He’s been developing software that learns to detect differences in voice patterns, in order to spot distinctive clues associated with Parkinson’s. Little explains to the BBC:

“This is machine learning. We are collecting a large amount of data when we know if someone has the disease or not and we train the database to learn how to separate out the true symptoms of the disease from other factors.”

Using data from 50 patients with Parkinson’s, who had their voices recorded once a week for six months, Little was able to develop an algorithm to detect changes in voice purely associated with Parkinson’s. In recent tests, the software accurately picked out Parkinson’s patients from a random population with 86 percent accuracy.

Now, Little is taking things further. Today, he is announcing at TEDGlobal that the project is extending, by inviting members of the general public to phone in and leave voice recordings to help him improve the software. The aim is to collect up to 10,000 voices, and people fromaround the world are encouraged to contribute.

If all goes well, Little hopes to roll out the technology for use by doctors in two years, and is adamant that it will help in the diagnosis of the disease. Again speaking to the BBC, he explained:

“We’re not intending this to be a replacement for clinical experts, rather, it can very cheaply help identify people who might be at high risk of having the disease and for those with the disease, it can augment treatment decisions by providing data about how symptoms are changing in-between check-ups with the neurologist.”

It’s an impressive achievement to take a relatively young technology and turn it into a system capable of detecting a disease like Parkinson’s. Now, if you excuse me, I have an important phone call to make. [Parkinson’s Voice Initiative via BBC]

NeuroDegeneration and Preserving the most Important Organ…The Brain!

Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. We are all suffering this process from birth. Some of use at a much accellerated rate than others. Glutathione plays a vital role in the stabilization of the NeuroDegenerative process. Glutathione protects the brain and nerves from oxidative stress. The oxidative stress that leads to the loss of the function of the brain. Many neurodegenerative diseases including Parkinson’sAlzheimer’s, and Huntington’s occur as a result of neurodegenerative processes. As research progresses, many similarities appear which relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.

The Oxidata™ Test

Click Here to Learn how to Test Your Free Radical Level in 5 Minutes – at Home!

Parkinsons and NeuroDegeneration. How to Stop or Slow this with Glutathione.

NeuroDegeneration and Preserving the most Important Organ…The Brain!

Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. We are all suffering this process from birth. Some of use at a much accellerated rate than others. Glutathione plays a vital role in the stabilization of the NeuroDegenerative process. Glutathione protects the brain and nerves from oxidative stress. The oxidative stress that leads to the loss of the function of the brain. Many neurodegenerative diseases including Parkinson’sAlzheimer’s, and Huntington’s occur as a result of neurodegenerative processes. As research progresses, many similarities appear which relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.

The Oxidata™ Test

Click Here to Learn how to Test Your Free Radical Level in 5 Minutes – at Home!

Your Test Results

Consider Signing up for the “7 Secrets to Raising Glutathione” to Learn more about protecting your brain from NeuroDegeneration.

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Testing for Brain Degeneration with the Oxidata test. A Way to Measure Parkinson’s Progression.

Test Your Free Radical Level in 5 Minutes – at Home!

ORDER A 4 MONTH OXIDATA TEST KIT HERE

The Oxidata™ Test enables you to determine the level of stress on your body caused by free radical activity.  People of all ages can benefit from knowing if they are getting enough antioxidants in their diets and nutritional supplements to effectively counteract free radical cell damage.

The Oxidata Test™ provides a useful nutritional guide in the form of a color chart that helps determine the amount of oxidative activity in the body and can be helpful in making appropriate lifestyle and dietary changes as well as monitoring Glutathione levels.

This one-time use, at-home urine test kitmeasures the level of free radicals in your system. Too many free radicals over a period of time leads to chronic diseases, cell damage and faster aging. Keeping track of your oxidation is really a measure of your Glutathione as Glutathione is your master antioxidant.

Causes of free radical damage

  • Heavy metals and petrochemicals in the environment and in our foods
  • Over-the-counter and prescription drugs
  • Cooked oils and fats
  • Radiation
  • Viruses, yeast and bacteria in the system
  • Low dietary anti-oxidants
  • Mental/emotional stress
  • Low Glutathione Levels

Everyone has heard of free radicals and the importance of antioxidants in the diet.  The Oxidata™ Test enables the user to measure the amount of oxidative stress the body is enduring and the results of antioxidant intervention.

Many, if not all disease, afflict the body through oxidative damage.  The free radical theory of aging says that it is the primary cause of aging itself.

Free radicals are like fire.  It is only when free radicals become unconfined and excessive and start attacking normal, healthy tissue that disease takes place.  This happens when antioxidant / Glutathione activity is inadequate.

ORDER A 4 MONTH OXIDATA TEST KIT HERE

Discover Your Need for Antioxidants

  • The Oxidata™ Test is the world’s first and only non-invasive urine test that measures the amount of free radicals or oxidants in the body within five minutes.
  • The Oxidata™ Test is an advanced patented technology available through GlutaGenic.com

Features

  • In-Office or At-Home Convenience
  • Quick 5-minute test
  • Scientifically Developed
  • This urine test provides higher accuracy than an MDA (malondialdehyde) blood test.  Accuracy is within the range of 90%.

The Oxidata Test Kit Includes:

  • Free Radical Activity Evaluation Color Chart
  • Evaluation Explanation
  • Urine cup, the testing vial, a pipette to add urine to the vial, and specific directions.
  • Each kit contains one test vial for one-time use.

Instructions

Supplemental Dietary Restrictions Prior To Using Your Oxidata Test:  The day before you use the test, do not take supplemental vitamins, such as vitamin C, vitamin B complex, or vitamin B-1 (thiamine), vitamin B-2 (riboflavin), vitamin B-3 (niacin, also known as pyridoxamine). Any oral intake of vitamins or medication that turns your urine to an excessively yellow color (Riboflavin) may interfere with your ability to interpret the reading of your value. If you are currently taking any medications consult with your physician about the results of this test. Also don’t take your Glutathione the day before.

Use the test at least once a week if the initial test shows high oxidative stress then reduce to once or twice a month after antioxidant supplementation has reduced it to a normal level. For optimal results, consult your healthcare practitioner before taking nutritional supplementation.

Place urine in cup and draw up one milliliter with the dropper. Break top off of ampoule and squeeze urine from dropper into ampoule. Wait five minutes; then hold ampoule up to evaluation chart to match colors. Record your reading on our Oxidata™ Test chart.

Frequency of Test

The frequency for the Oxidata™ Test varies with each individual. If an individual test color is in the high free radical range, the person should begin or increase antioxidant supplementation and retest at least twice a month until free radical activity has been reduced. The Oxidata™ Test should be taken once a month thereafter.

ORDER A 4 MONTH OXIDATA TEST KIT HERE

Your Test Results

If your score is high we recommend that you consider Signing up for the “7 Secrets to Raising Glutathione” as well as Glutathione Supplementation.

Thank You for Joining me Today!