Chronic systemic pesticide exposure reproduces features of Parkinson’s disease.

Ranjita Betarbet^1, 2, Todd B. Sherer^1, 2, Gillian MacKenzie¹, Monica Garcia-Osuna¹, Alexander V. Panov¹ & J. Timothy Greenamyre¹

¹  Department of Neurology, Emory University, 1639 Pierce Drive, WMB 6000, Atlanta, Georgia 30322, USA

The cause of Parkinson’s disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic defect in mitochondrial complex I. We report that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and -synuclein. These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD.

Comment:

How can you protect yourself? Glutathione acts like fly paper and wraps around then carries the toxins such as heavy metals and pesticides out of the body. Reseaech has proven that PArkinson’s in due to oxidative stress in the S. Nigra in the brain and low Glutathione levels contribute to the damage. Protecting your brain by supplementing with Glutathione is a smart choice. Remember you cann’t take Glutathione orally so suppositories and nebulization are a great option.