This study evaluates the therapeutic efficacy of the NADPH oxidase inhibitor apocynin, isolated as principal bioactive component from the medicinal plant Picrorhiza kurroa, in a marmoset MPTP model of Parkinson’s disease (PD). The methoxy-substituted catechol apocynin has a similar structure as homovanillic acid (HVA), a metabolite of dopamine (DA). Apocynin acquires its selective inhibitory capacity of the reactive oxygen species generating NADPH oxidase via metabolic activation by myeloperoxidase (MPO). As MPO is upregulated in activated brain microglia cells of PD patients and in MPTP animal models, the conditions for metabolic activation of apocynin and inhibition of microglia NADPH oxidase are in place. Marmoset monkeys received oral apocynin (100 mg/kg; p.o.) (n = 5) or Gum Arabica (controls; n = 5) three times daily until the end of the study, starting 1 week before PD induction with MPTP (1 mg/kg s.c. for 8 days). Parkinsonian symptoms, motor function, home-cage activity and body weight were monitored to assess the disease development and severity. Post-mortem numbers of the tyrosine hydroxylase expressing DA neurons in the substantia nigra were counted. During the MPTP injections, apocynin limited the body weight loss and relieved parkinsonian symptoms compared to controls (Linear regression, P < 0.05) indicating a reduction of disease progression. During the last test week, apocynin also improved the hand-eye coordination performance compared with vehicle treatment (resp. 39.3 ± 4.5 % and 17.7 ± 6.7 %; P = 0.048) and improved the home cage activity with 32 % (P = 0.029), indicating anti-Parkinson efficacy. Apocynin also increased the number of surviving DA neurons in MPTP-treated marmosets with 8.5 % (P = 0.059), indicating a tendency towards a neuroprotective efficacy. In conclusion, compensation for the loss of DA and its metabolite HVA by apocynin mitigates the PD progression and limits the parkinsonian signs and motor-function deterioration.
Glutathione is a powerful antioxidant and works to selective inhibitory capacity of the reactive oxygen species generating NADPH oxidase via metabolic activation by myeloperoxidase (MPO) as well. As MPO is upregulated in activated brain microglia cells of PD patients where the conditions for metabolic activation of oxidation leading to microglia NADPH oxidase, Glutathione also acts to inhibit this microglia activation as well. There has been some fare success in our office with PD patients to combine Glutathione or GlutaMax with Picrorhiza. Breathe from MitoZen offers Apocynin! Please contact us for more information.
FCR is a natural approach to treatment of Parkinson’s Disease. Using saccadometry to measure the eye saccade can be of great help to measure issues parkinson’s patients commonly have with omnipause intrusions. This devices also can be helpful to measure effectiveness of treatments. Dr. John uses Endo-Nasal adjusting, Glutathione, PEMF of the brain, and Brain exercises that are targeted to the Dopamine producing neurons in the brain to activate them in order to keep them healthy and get them to produce dopamine naturally. Dr. John Lieurance has been pioneering the use of these modalities to treat parkinson’s for several years. He is a Chiropractic Neurologist and is located in Sarasota Florida.
FCR is a natural approach to treatment of Parkinson’s Disease. Using Endo-Nasal adjusting, Glutathione, PEMF of the brain, and Brain exercises that are targeted to the Dopamine producing neurons in the brain to activate them in order to keep them healthy and get them to produce dopamine naturally. Dr. John Lieurance has been pioneering the use of these modalities to treat parkinson’s for several years. He is a Chiropractic Neurologist and is located in Sarasota Florida.
Dr. John, I am sitting in my home in Texas considering the events of this past week. As I become more and more aware of how much better I feel physically and mentally, I am overwhelmed with emotion! Thank you from the bottom of my heart for what you do! I have so much hope for the future! Praise God, that you are using your gift He has bestowed upon you! You are doing a monumental work! Your friend, CG – Texas
NeuroDegeneration and Preserving the most Important Organ…The Brain!
Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. We are all suffering this process from birth. Some of use at a much accellerated rate than others. Glutathione plays a vital role in the stabilization of the NeuroDegenerative process. Glutathione protects the brain and nerves from oxidative stress. The oxidative stress that leads to the loss of the function of the brain. Many neurodegenerative diseases including Parkinson’s, Alzheimer’s, and Huntington’s occur as a result of neurodegenerative processes. As research progresses, many similarities appear which relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death.Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.
Restless legs syndrome (RLS) is a neurological disorder characterized by throbbing, pulling, creeping, or other unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them. Symptoms occur primarily at night when a person is relaxing or at rest and can increase in severity during the night. Moving the legs relieves the discomfort. Often called paresthesias (abnormal sensations) or dysesthesias (unpleasant abnormal sensations), the sensations range in severity from uncomfortable to irritating to painful.
The most distinctive or unusual aspect of the condition is that lying down and trying to relax activates the symptoms.
Considerable evidence suggests that RLS is related to a dysfunction in the brain’s basal ganglia circuits that use the neurotransmitter dopamine, which is needed to produce smooth, purposeful muscle activity and movement. Disruption of these pathways frequently results in involuntary movements. Individuals with Parkinson’s disease, another disorder of the basal ganglia’s dopamine pathways, often have RLS as well.
Some studies show that RLS can be an early symptom of Parkinson’s disease.
Any person who has the signs and symptoms characteristic of Parkinson’s disease is said to have parkinsonism, but not every person with parkinsonism has Parkinson’s disease, it’s only one of the possibilities.
Patients and their families need to understand parkinsonism, because some 20 to 25 percent of people diagnosed with Parkinson’s disease will eventually be discovered to have some other form of parkinsonism. Parkinsonism may look like Parkinson’s disease, but over time it does not act like it.
For this reason, if you have been diagnosed with Parkinson’s disease it is important to see a neurologist who has experience diagnosing and treating this disorder.
NAD+ stands for Nicotinamide Adenine Dinucleotide, and is an essential molecule found in every cell of your body. It is a coenzyme of Vitamin B3 (niacin), which means it’s a small helper molecule that binds to a protein molecule in order to activate an enzyme. Enzymes are responsible for over 5,000 different biochemical reactions throughout the body and NAD+participates in more reactions than any other vitamin-derived molecule.
What does NAD+ do?
NAD+ stands for Nicotinamide Adenine Dinucleotide, and is an essential molecule found in every cell of your body. It is a coenzyme of Vitamin B3 (niacin), which means it’s a small helper molecule that binds to a protein molecule in order to activate an enzyme. Enzymes are responsible for over 5,000 different biochemical reactions throughout the body and NAD+participates in more reactions than any other vitamin-derived molecule.
ENERGY PRODUCTION– NAD+ helps your cells convert food into energy by acting as an electron transporter during cell metabolism.
Repair DNA – A constant supply of NAD+ is needed for the activation of PARPs, which detect and repair damaged DNA.
Enzyme Activty – A class of enzymes called sirtuins help regulate certain metabolic pathways and genetic expressions. Sirtuins are NAD-dependent and the more sirtuin activity, the better for health and longevity. Increased sirtuin activity can help increase metabolism, decrease inflammation, extend cell life, and prevent neurodegeneration.
Cell Signaling– NAD+ is also released from the intercellular space to the extracellular space for communication. Research is revealing that NAD and ATP may alert the immune response when the cell is under stress or when there is inflammation.
Neurotransmitter– Although more research still needs to be conducted, in some instances, NAD+ meets the pre- and postsynaptic criteria for a neurotransmitter. NAD+ is released from smooth muscle, neurosecretory cells, and brain synaptosomes for cell-to-cell communication. NAD helps the enzyme pathway from tyrosine to dopamine which is compromised in Parkinsons Disease.
Gene Expression– A class of enzymes called sirtuins help regulate certain metabolic pathways and genetic expressions. Sirtuins are NAD-dependent and the more sirtuin activity, the better for health and longevity. Increased sirtuin activity can help increase metabolism, decrease inflammation, extend cell life, and prevent neurodegeneration.
NAD+ and NADH are used in processes such as metabolizing alcohol and converting lactate to pyruvate in the body.
What is NAD+ Therapy?
NAD+ Therapy involves a high dose intravenous infusion of NAD+ that goes straight into the bloodstream. IV therapy allows NAD+ to bypass the digestive system for better absorption. NAD+ works rapidly to repair cells throughout the body and neurons in the brain.
Every client has an individualized protocol based on the condition, so treatment length can vary from 4 to 12 days. Clients receive a high dose IV therapy under the supervision of Dr. Milgram and qualified nurses. The therapy is administered in a calm, holistic outpatient setting that allows working professionals the flexibility they need and out-of-towners the opportunity to see the beautiful city of Sarasota, Florida.
NAD+ therapy anecdotally has a synergistic effect when combined with other innovative therapies offered at advanced rejuvenation. These include:
Whole Body Cryotherapy
Hyperbaric Oxygen Therapy
Naturopathic Nutritional Support
Functional Chiropractic Neurology
Stem Cell Therapy
Acupuncture
Platelet Rich Plasma
Prolozone
IV Laser Therapy
Benefits of NAD+ Therapy
When your NAD+ levels are increased, your cells produce more energy, your good genes are “turned on”, DNA is repaired, and many other functions are optimized. Since NAD+ is such a powerful and prolific molecule in the body, high dose IV therapy can be helpful for many different conditions including:
Our clinic is a certified provider of a proprietary NeuroREJUVENATION ™ Therapy developed by Advanced Rejuvenation, the first and longest operating NAD+ clinic in Florida. Call or email for a FREE consultation. 941 330-8553 or AskdoctorJL@Gmail.com
Glutathione and Parkinsions- Genetics show sufferers of PD have low Glutathione levels!
Explore Glutathione Suppository and Parkinsons.
Watch these video’s of patient’s receiving our treatments.
Understanding the brain and nervous system is at the core of many health challenges is crucial in understanding why FCR works so well on Parkinson’s Disease. Your brain and nervous system control every aspect of your body’s response to stress, like mental stress, emotional stress, structural stress, toxic stress, and even infections.
By balancing your brain you balance your body’s response to stress and it’s environment.
“The Nervous System Controls and Coordinates all the Systems of the Body and Relates the Individual to Their Environment” Gray’s Anatomy, 24th edition, pg.46
Functional Cranial-Release is the art and science of restoring normal brain and nervous system function by using Functional Neurology along with specific endo-nasal balloon manipulation to accomplish the following:
1) Restore the brains ability to oxygenate itself through both improving air flow into higher area’s through the nasal passage and also improve the normal pumping action inherent in all of use (cranial rhythm) that moves nutrients such as oxygen and neurotransmitters that bath the central nervous system keeping it healthy. This can be helpful to better distribute Dopamine around the specific areas of the brain! Also better nutrient supply to areas such s the substantia nigra!
2) Utilize neurologic testing to determine the pathways and brain centers that are viable area’s to support better substantial nigra integrity and dopamine producing areas of the brain. Area that can support a Parkinson’s sufferer can be explored using the following; Examination of your eye’s movements and reflex’s which can be a major problem with Parkinson’s such as poor saccade function and poor smooth eye pursuit! In Parkinsons There are specific areas of the brain that shut down and cause many of the symptoms such as slowness of movement, tremor, stiffness, constipation and poor balance. With FCR we look through these systems with testing such as a saccadometer test and other neurological testing to see how this is showing up in your specific case. Also the muscles or motor system, the autonomic nervous system, your circulation, your sensory system, the vestibular system (or) your ability to balance. Through the specific use of various modalities such as one or more of the following; Very Specific cranial adjustments along with specific neurological exercises to include such ones as Eye Pattern & Eye Exercise’s, Canalith Repositioning (or) Eply’s, Vestibular Rehabilitative Modalities or VRT, and many others too numerous to list. We also utilize Glutathione therapies. The modalities used depend on the specific needs of the patient. Please sign up for the 7 secrets to raising glutathione at the bottom of this page for a free video course by Dr John.
3) A series Cranial Release’s are performed where the connective tissues that surround your brain and spinal cord called the Dura Mater are specifically released using endonasal balloon inflations. This is done in combination with the above mentioned functional neurologic modalities to provide the therapeutic effect to balance and normalize brain function. This normalization results in healing and management of Parkinson’s associated with neurodegenerative dis-orders.
Glutathione
See Glutathione at GlutaGenic.com for exciting delivery systems for boosting brain function and allowing healing and improvement from neurological conditions. This is often used like the oxygen to allow a greater window for driving brain healing through FCR. Often your brains metabolic state can be a limiting factor in doing certain activities that can be of benefit to your brain. Oxygen and Glutathione can open some doors for you in this area.
Watch this demonstration of FCR being performed.
Here is a video demonstrating FCR with a Vertigo and Migraine Patient.
What others are saying about FCR.
Call (941) 330-8553 for an appointment.
You can also request a phone consultation if you are out of town.
